Core Facilities
MMRI has 31,000 square feet of space including laboratories, offices, library, conference rooms, common areas, and kitchen. We are conveniently located in the heart of Silicon Valley, a few minutes from Stanford University, the NASA space research center, and numerous biotechnology companies. The Institute occupies a modern facility capable of supporting our efforts in molecular biology, immunology, cell biology, synthetic organic chemistry and is supported by a complete analytical chemistry laboratory.
Cellular and Molecular Biology
The Cellular and Molecular Biology Laboratory at MMRI provides outstanding technical and scientific support for scientists within the Institute as well as our collaborators. Capabilities include:
In vitro
- Tissue culture
- Cell biology
- Molecular biology
Assay Technology
- ELISA
- Bioluminescence
- FACS
Radioisotopic assay technologies
Proteomics
Histology
- Immunohistochemistry
- Fluorescent microscopy and image capture
Selected Equipment
- Fluorescent microscope (inverted)
- RT PCR
- 96-well UV-Vis and fluorescence/ luminescence spectrophometers
- Cell culture rooms equipped with biosafety cabinets
- Electrophoresis
- Packard Topcount NXT (microplate liquid scintillation and luminescence)
- Beckman LS 6500 liquid scintillation counter
- LKB Wallac 1274 RiaGamma automatic gamma counter
- Centrifuges (ultra, low speed, and bench top)
- Fume hoods
- Phosphorimager
- Cryostats and microtomes
- Perkin Elmer Piezorray high precision and high density microarraying system
- Lyophilizer
The Medicinal Chemistry Laboratory at MMRI is a modern facility with state-of- the-art equipment for small to medium scale synthesis, purification, and identification. Capabilities include:
Small to medium scale synthesis
Identification by MS and HPLC
Separation and purification by preparative HPLC
Purification
Selected Equipment
- Fume hoods
- Rotovaps
- Extensive collection of specialized chemistry glassware
- Vacuum pumps and circulating water vacuum aspirators
- Gas chromatographs (FID and TCD)
- Agilent 1100 LC-MSD (Electrospray and APCI)
- Preparative and analytical HPLCs with UV-vis diode array detection
- Teledyne CombiFlash automated synthesis systems
The Analytical Chemistry Laboratory at MMRI provides outstanding analytical support for internal research and in support of external collaborations. Capabilities include:
Mass Spectrometry
- Molecular mass characterization
- Quantitation of molecules in complex mixtures, formulations and biological matrices
- Custom Analysis
HPLC
- Methods development
- HPLC purity analysis
- Quantitation of compounds in solution
- Purification of compounds by preparative HPLC
Selected Equipment
- Gas Chromatographs (FID and TCD)
- Agilent 1100 LC-MSD (Electrospray and APCI)
- Preparative and analytical HPLCs with UV-vis diode array detection
- API 5000 LC/MS/MS
- DEA Licenses
- Environmental Protection Agency Licenses
- Environmental Health and Safety
- Hazardous Material Licenses
- Irradiation License
- Radioactive Materials License
